Predictions for hand surgery advances over the first 25 years of the new mi
llenium are made. Anticipated changes are categorized as societal, technolo
gic, and research with clinical applications. Certainly advances in compute
r science and molecular biology will affect all aspects of our lives. Withi
n hand surgery, tissue engineering, materials science, and nanotechnology o
ffer great promise. (J Hand Surg 2001;26A:3-7. Copyright (C) 2001 by the Am
erican Society for Surgery of the Hand.).