Pneumocystis carinii cytochrome b mutations are associated with atovaquoneexposure in patients with AIDS

Citation
P. Kazanjian et al., Pneumocystis carinii cytochrome b mutations are associated with atovaquoneexposure in patients with AIDS, J INFEC DIS, 183(5), 2001, pp. 819-822
Citations number
15
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00221899 → ACNP
Volume
183
Issue
5
Year of publication
2001
Pages
819 - 822
Database
ISI
SICI code
0022-1899(20010301)183:5<819:PCCBMA>2.0.ZU;2-Z
Abstract
This retrospective cohort study was conducted to determine whether Pneumocy stis carinii cytochrome b gene mutations in patients with AIDS and P. carin ii pneumonia (PCP) are associated with atovaquone exposure. Portions of the P. carinii cytochrome b genes that were obtained from 60 patients with AID S and PCP from 6 medical centers between 1995 and 1999 were amplified and s equenced by using polymerase chain reaction. Fifteen patients with previous atovaquone prophylaxis or treatment exposure were matched with 45 patients with no atovaquone exposure. Cytochrome b coenzyme Q binding site mutation s were observed in 33% of isolates from patients exposed to atovaquone, com pared with 6% from those who were not (P = .018). There was no difference i n survival 1 month after treatment between patients with or without cytochr ome b mutations (P = .14). Thus, cytochrome b mutations are significantly m ore common in patients with AIDS and PCP with atovaquone exposure, but the clinical significance of these mutations remains unknown.