Midfacial granuloma syndrome or an inflammatory non-specific disease? A case report

We report a case of idiopathic midline destructive disease in a 57-year-old man. The patient had a non-specific histological pattern in biopsies obtai ned from the nose and upper lip, characterized by a granulomatous reaction with progressive destruction of the tissues. The patient's general medical history was non-contributory. Clinical and laboratory data did not support any feasible etiology for this destructive process. The patient was treated with prednisone until the discovery of type II diabetes mellitus (never di agnosed before) and was then in turn treated only with oral antidiabetic th erapy, Follow-up controls revealed progressive reduction of the symptoms an d of the nasal and lip lesions and total remission of symptoms up to 2 year s after the onset of the disease. We discuss the diagnostic and subsequent therapeutic problems in the management of the midline necrotizing lesions.