Conformational analysis of the dinucleotides d(TpA, TpT, TpG and TpC) in different solvents

Authors
Arnold, JRP Baker, JM Beevers, APG Elliott, M Fisher, J
Citation
Jrp. Arnold et al., Conformational analysis of the dinucleotides d(TpA, TpT, TpG and TpC) in different solvents, MAGN RES CH, 39(2), 2001, pp. 109-112
Citations number
23
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
MAGNETIC RESONANCE IN CHEMISTRY
ISSN journal
07491581 → ACNP
Volume
39
Issue
2
Year of publication
2001
Pages
109 - 112
Database
ISI
SICI code
0749-1581(200102)39:2<109:CAOTDD>2.0.ZU;2-U
Abstract
The 2'-deoxyribose conformations in four natural dinucleotides, TpX (where X is T, dC, dA or dG), dissolved in D2O, CD3OD and DMSO-d(6) were investiga ted by H-1 NMR spectroscopy. Accurate chemical shifts and coupling constant s derived by simulation of 1H spectra are reported. Sugar pucker parameters derived from vicinal coupling constants are also presented. It is noted th at there is no simple relation between sugar conformations and solvent prop erties. Copyright (C) 2001 John Wiley & Sons, Ltd.