Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain

We report the identification of a fourth member of the VPS10 domain contain ing receptor family, SorCS2, highly expressed in the developing and mature murine central nervous system. During early central nervous system developm ent its main site of expression is the floor plate. In addition, high trans cript levels were detected transiently in a variety of brain regions includ ing the dopaminergic midbrain nuclei and the dorsal thalamus. Outside the n ervous system expression is detected in lung and heart and transiently in a variety of mesodermally derived tissues. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.