Afm. Verbraak et al., A new approach to mechanical simulation of lung behaviour: pressure-controlled and time-related piston movement, MED BIO E C, 39(1), 2001, pp. 82-89
A mechanical lung simulator is described (an extension of a previous mechan
ical simulator) which simulates normal breathing and artificial ventilation
in patients. The extended integration of hardware and software offers many
new possibilities and advantages over the former simulator. The properties
of components which simulate elastance and airway resistance of the lung a
re defined in software rather than by the mechanical properties of the comp
onents alone. Therefore, a more flexible simulation of non-linear behaviour
and the cross-over effects of lung properties is obtained. Furthermore, th
e range of lung compliance is extended to simulate patients with emphysema.
The dependency of airway resistance on lung recoil pressure and transmural
pressure of the airways can also be simulated. The new approach enables on
e to incorporate time-related mechanics such as the influence of lung visco
sity or cardiac oscillation. The different relations defined in the softwar
e can be changed from breath to breath.
Three simulations are presented: (1) computer-controlled expiration in the
artificially ventilated lung; (2) simulation of normal breathing; and (3) s
imulation of viscoelastance and cardiac influences during artificial ventil
ation. The mechanical simulator provides a reproducible and flexible enviro
nment for testing new software and equipment in the lung function laborator
y and in intensive care, and can be used for instruction and training.