Cellular and molecular mechanisms of internalization of mycobacteria by host cells

Mycobacteria are intracellular pathogens capable of invading mononuclear ph agocyte, mucosal epithelial cells (including M cells) and Schwann cells. To enter cells, mycobacteria have been shown to interact with several molecul es on macrophage and epithelial cell surfaces. This suggests adaptation to the host environment. In this review we address the strategies used by path ogenic mycobacteria to gain access to the intracellular environment. (C) 20 01 Editions scientifiques et medicales Elsevier SAS.