The Quellung reaction provides a standard means for serotyping Streptococcu
s pneumoniae, but it requires microscopic examination with skillful techniq
ue, We have developed an improved agglutination method with anti-rabbit IgG
-coated latex particles, which are sensitized with pooled antisera for sero
typing/serogrouping S. pneumoniae. Our method is as specific and sensitive
as the Quellung test, and much easier to perform.