Comparison of thalamotomy to deep brain stimulation of the thalamus in essential tremor

OBJECTIVE: To compare outcome in Essential Tremor (ET) patients who have un dergone either thalamotomy or Deep Brain Stimulation (DBS) of the thalamus. BACKGROUND: Although both thalamotomy and thalamic DBS are effective surgic al treatments of tremor, it is not known if one procedure is superior to th e other. DESIGN/METHODS: Thirty-five ET patients underwent thalamotomy between 1994- 1998. Data on 18 patients were excluded. The remaining 17 patients were mat ched for age, sex, side of surgery, and tremor severity to 17 ET patients w ho underwent thalamic DBS. There were nine men and eight women in each grou p. The mean age of the thalamotomy group was 74.4 years and that of the tha lamic DBS group was 73.1 years. RESULTS: There were no significant differences between any efficacy outcome variables comparing thalamotomy to DBS of the thalamus at baseline or foll ow-up visits. The surgical complications were higher for the thalamotomy gr oup as compared to the DBS group. However, a larger number of DBS patients underwent repeat surgeries due to problems with the device and the leads. CONCLUSION: Although the efficacy is similar for thalamotomy and DBS of the thalamus for ET, thalamotomy is associated with a higher complication rate . DBS of the thalamus should be the procedure of choice for the surgical tr eatment of ET in most cases.