Expressing the human genome

We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre- messenger RNA splicing and polyadenylation. A plethora of potential new fac tors are implicated by sequence in nuclear gene expression, revealing a sub stantial but selective increase in complexity compared with Drosophila mela nogaster and Caenorhabditis elegans. Although the raw genomic information h as limitations, its availability offers new experimental approaches for stu dying gene expression.