Genomics, the cytoskeleton and motility

The draft human genome sequence is an important step in cataloguing the mol ecular hardware that supports the processes of life. Here I look at what we have learned from the draft sequence about our cytoskeletal and motility s ystems. Most cytoskeletal and motility proteins were discovered previously by biochemical isolation, traditional cloning methods or random sequences o f complementary DNAs. The ongoing challenges of assembling and annotating g enes for motor proteins with long, fragmented coding sequences emphasize th e importance of expert knowledge of related proteins and confirmatory evide nce from cDNA sequences.