Chemokines as regulators of T cell differentiation

Citation
Sa. Luther et Jg. Cyster, Chemokines as regulators of T cell differentiation, NAT IMMUNOL, 2(2), 2001, pp. 102-107
Citations number
108
Categorie Soggetti
Immunology
Journal title
NATURE IMMUNOLOGY
ISSN journal
15292908 → ACNP
Volume
2
Issue
2
Year of publication
2001
Pages
102 - 107
Database
ISI
SICI code
1529-2908(200102)2:2<102:CAROTC>2.0.ZU;2-S
Abstract
Chemokines play well established roles as attractants of naive and effector T cells. New studies indicate that chemokines also have roles in regulatin g T cell differentiation. Blocking G(i) protein-coupled receptor signaling by pertussis toxin as well as deficiencies in G alpha (i2), chemokine recep tor 2 (CCR2), CCR5, chemokine ligand 2 (CCL2, also known as monocyte chemoa ttractant protein 1, or MCP-1), CCL3 (macrophage inflammatory protein 1 alp ha, or MIP-1 alpha) and CCL5 (RANTES) have all been found to have effects o n the magnitude and cytokine polarity of the T cell response. Here we focus on findings in the CCL2-CCR2 and CCL3-CCR5 ligand-receptor systems. The ro les of these molecules in regulating T cell fate include possible indirect effects on antigen-presenting cells and direct effects on differentiating T cells. Models to account for the action of chemokines and G protein-couple d receptor signals in regulating T cell differentiation are discussed.