Chemokines and disease

We examine here several diseases that are associated with inappropriate act ivation of the chemokine network. Detailed comment has been restricted to p athological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, aller gic inflammatory disease, transplantation, neuroinflammation, cancer and HI V-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed.