Two organizing centres operate at long-range distances within the anterior
neural plate to pattern the forebrain, midbrain and hindbrain. important pr
ogress has been made in understanding the formation and function of one of
these organizing centres, the isthmic organizer, which controls the develop
ment of the midbrain and anterior hindbrain. Here we review our current kno
wledge on the identity, localization and maintenance of the isthmic organiz
er, as well as on the molecular cascades that underlie the activity of this
organizing centre.