Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats

Authors
Germano, MP D'Angelo, V Mondello, MR Pergolizzi, S Capasso, F Capasso, R Izzo, AA Mascolo, N De Pasquale, R
Citation
Mp. Germano et al., Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats, N-S ARCH PH, 363(2), 2001, pp. 241-244
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
ISSN journal
00281298 → ACNP
Volume
363
Issue
2
Year of publication
2001
Pages
241 - 244
Database
ISI
SICI code
0028-1298(200102)363:2<241:CCIOSG>2.0.ZU;2-8
Abstract
The effect of cannabinoid drugs (i.p.) on cold/ restraint stress-induced ga stric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55, 212-2, 0.11 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB, receptor antagonist SR141716A, but not by the cannabinoid CB, receptor antagonist SR144528. These results ind icate that the antiulcer effect of the cannabinoid receptor agonist WIN 55, 212-2 is mediated by cannabinoid CBI receptors.