Cd. Daly et al., Do the Y-set and double-bag systems reduce the incidence of CAPD peritonitis? A systematic review of randomized controlled trails, NEPH DIAL T, 16(2), 2001, pp. 341-347
Background. Peritonitis is the most frequent serious complication of contin
uous ambulatory peritoneal dialysis (CAPD). It has a major influence on the
number of patients switching from CAPD to haemodialysis and has probably r
estricted the wider acceptance and uptake of CAPD as an alternative mode of
dialysis. This systematic review sought to determine if modifications of t
he transfer set (Y-set or double-bag systems) used in CAPD exchanges are as
sociated with a reduction ill peritonitis and an improvement in other relev
ant outcomes.
Methods. Based on a comprehensive search strategy, we undertook a systemati
c review of randomized or quasi-randomized controlled trials comparing doub
le-bag and/or Y-set CAPD exchange systems with standard systems, or compari
ng double-bag with Y-set systems, in patients with end-stage renal disease
(ESRD) treated with CAPD. Only published data were used. Data were abstract
ed by a single investigator onto a standard form and subsequently enter-ed
into Review Manager 4.0.4. Its statistical package, Metaview 3.1, calculate
d an odds ratio (OR) for dichotomous data and a (weighted) mean difference
for continuous data with 95%, confidence intervals.
Results. Twelve eligible trials with a total of 991 randomized patients wer
e identified. In trials comparing either the Y-set or double-bag systems wi
th the standard systems, significantly fewer patients (133/363 vs 158/263;
OR 0.33, 95% CI 0.24-0.46) experienced peritonitis and the number of patien
t-months on CAPD per episode of peritonitis was consistently greater. When
the double-bag systems were compared with the Y-set systems significantly f
ewer patients experienced peritonitis (44/154 vs 66/138; OR 0.44, 95% CI 0.
27-0.71) and the number of patient-months on CAPD per episode of peritoniti
s was also greater.
Conclusions. Double-bag systems should be the preferred exchange systems in
CAPD.