Prepro-galanin messenger RNA levels are increased in rat locus coeruleus after treadmill exercise training

Citation
Ha. O'Neal et al., Prepro-galanin messenger RNA levels are increased in rat locus coeruleus after treadmill exercise training, NEUROSCI L, 299(1-2), 2001, pp. 69-72
Citations number
23
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
299
Issue
1-2
Year of publication
2001
Pages
69 - 72
Database
ISI
SICI code
0304-3940(20010216)299:1-2<69:PMRLAI>2.0.ZU;2-S
Abstract
The effects of treadmill exercise training on prepro-galanin (GAL) and tyro sine hydroxylase (TH) gene expression in the locus coeruleus (LC) were exam ined. Male Fischer-344 rats (n = 9) were assigned to 6 weeks of treadmill r unning. An additional group of animals comprised the sedentary home cage co ntrol group (n = 9). Levels of GAL and TH messenger RNA (mRNA) in the LC we re measured using in situ hybridization histochemistry with autoradiography . Levels of GAL mRNA were higher in treadmill trained animals compared to s edentary animals, but there was no effect of treadmill running on TH mRNA. These results suggest that gene expression for galanin is responsive to rep eated exercise stress and may have a neuromodulatory role in LC-noradrenerg ic adaptation to treadmill exercise training. (C) 2001 Elsevier Science Ire land Ltd. All rights reserved.