Immunohistochemical evidences for localization and production of D-serine in some neurons in the rat brain

D-Amino acids are thought not to occur in mammalian tissues. However, previ ous studies reported D-serine was present only in astrocytes in the rat bra in. In the present study, it was indicated by a highly sensitive immunocyto chemical method with a D-serine specific antibody that D-serine was contain ed not only in astrocytes but also in some neurons, such as pyramidal neuro ns in the cerebral cortex, and neurons in the nucleus of the trapezoid body . Some amacrine cells also showed strong immunoreactivity for D-serine in t he eyes which were injected with colchicine into the corpus vitreum. (C) 20 01 Elsevier Science Ireland Ltd. All rights reserved.