Exploiting the Curtin-Hammett principle-recognition-mediated acceleration of an aldol reaction

Authors
Howell, SJ Ashton, PR Spencer, N Philp, D
Citation
Sj. Howell et al., Exploiting the Curtin-Hammett principle-recognition-mediated acceleration of an aldol reaction, ORG LETT, 3(3), 2001, pp. 353-356
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
3
Year of publication
2001
Pages
353 - 356
Database
ISI
SICI code
1523-7060(20010208)3:3<353:ETCPAO>2.0.ZU;2-J
Abstract
[GRAPHICS] Curtin-Hammett-Winstein-Holness kinetics are exploited in the acceleration of the aldol reaction between formylbenzo-15-crown-5 and acetylbenzo-15-cro wn-5. Potassium cations facilitate this acceleration through the fast, reve rsible formation of a 1:1:1 sandwich complex between the crown ethers and t he metal cation.