Pathological study of postcoronary arteritis in adolescents and young adults: With reference to the relationship between sequelae of Kawasaki diseaseand atherosclerosis

To clarify whether the cardiac sequelae of Kawasaki disease (KD), postcoron ary arteritis lesions can become a risk factor for atherosclerosis of the c oronary arteries, six autopsy cases of patients older than 15 years of age with coronary arterial lesions caused by arteritis in childhood were examin ed histologically. Twenty-four arteries were inspected: 10 had no evidence of aneurysm formation, 7 arteries manifested simple dilatation of the lumen , and in 7 arteries there were aneurysms with recanalization. In the group in which there were no aneurysms, "new intimal thickening" was observed in addition to the preexisting intimal thickening which had been caused by art eritis in the acute phase of KD. In the second group with aneurysmal arteri es whose lumen remained dilated, thrombotic occlusion occurred in 4 of 6 an eurysms. In addition, advanced atherosclerotic changes (i.e., complicated l esions) were found in a 39-year-old patient. Finally, in the third group of arteries which manifested recanalized lumens after thrombotic occlusion of the aneurysms, new intimal thickening was seen on the internal side and so me of them were occluded. The findings in this study suggest that aneurysms present in coronary arteries in individuals with a history of KD constitut e a risk factor for atherosclerosis later in life.