Separation of nicotine metabolites by capillary zone electrophoresis and capillary zone electrophoresis/mass spectrometry

Authors
Palmer, ME Smith, RF Chambers, K Tetler, LW
Citation
Me. Palmer et al., Separation of nicotine metabolites by capillary zone electrophoresis and capillary zone electrophoresis/mass spectrometry, RAP C MASS, 15(3), 2001, pp. 224-231
Citations number
22
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
ISSN journal
09514198 → ACNP
Volume
15
Issue
3
Year of publication
2001
Pages
224 - 231
Database
ISI
SICI code
0951-4198(2001)15:3<224:SONMBC>2.0.ZU;2-E
Abstract
The use of capillary zone electrophoresis (CZE) and capillary zone electrop horesis/mass spectrometry (CZE/MS) has been demonstrated, in principle, for the separation of nicotine and nicotine metabolites. The buffer system dev eloped for separation and detection by CZE/UV was modified for use in CZE/M S analysis. Several of the metabolites are isobaric and tandem mass spectro metric (MS/MS) techniques have been used to differentiate such analytes. Co pyright (C) 2001 John Wiley & Sons, Ltd.