Dopamine transporter density in young patients with schizophrenia assessedwith [(123)] FP-CIT SPECT

Disturbances in the dopamine (DA) system are thought to play a major role i n schizophrenia. Amphetamine-induced release of endogenous DA is shown to b e enhanced in schizophrenia, as is striatal [F-18]FDOPA uptake in the stria tum. It is not clear if the density of DA neurons is altered in schizophren ia. By studying the DA transporter with [I-123]FP-CIT single photon emissio n computed tomography (SPECT), the density of nigrostriatal dopaminergic ce lls can be studied. Using [I-123]FP-CIT SPECT, DA transporter density in the striatum was studi ed in 36 young patients with schizophrenia, Ten patients were antipsychotic (AP)-naive, 15 were treated with olanzapine. eight with risperidone and th ree were AP-free. A control group of 10 age-matched volunteers was included . Striatal [I-123]FP-CIT binding was not significantly different between AP-n aive patients (2.87), patients treated with olanzapine (2.76). patients tre ated with risperidone (2.76). AP-free patients (7.68) and controls (2.82) ( F=0.07. p=0.98). Unexpectedly, striatal [I-123]FP-CIT binding in females wa s significantly higher than in males (3.29 and 2.70, respectively; t = -2.5 6, p = 0.014). Concluding, functional changes in the dopaminergic system in schizophrenia are not likely to be reflected in a change in DA transporter density. Moreo ver. DA transporter density does not seem to be altered by AP medication. ( C) 2001 Elsevier Science B.V. All rights reserved.