A quantitative MR measure of the fornix in schizophrenia

Some cognitive disturbances accompanying schizophrenia may be due to abnorm alities in the thalamus and components of the limbic system. The fornix is an important white-matter relay pathway connecting these structures and is likely to be affected in schizophrenia as well. Magnetic resonance images of the fornix were analyzed in 15 schizophrenic p atients and 15 matched comparison group subjects. Fornix volume was compare d between the two groups and was also correlated with the volumes of other neuroanatomical structures, as well as with illness presentation, clinical status, and cognitive/psychological measures. There was no significant difference in fornix volume between the two groups . Of note, fornix volume correlated significantly with the volumes of the h ippocampus, parahippocampus. and the superior temporal gyrus in the schizop hrenic subjects, but not in the controls. Moreover. the correlation between Fornix and parahippocampal gyrus volumes differed significantly between th e two groups. No association was found between fornix volume and illness pr esentation or between fornix and cognitive/clinical measures. Results suggest that there are no marked changes in fornix volume in schizo phrenia by MRI. The fornix, however. may be part of a network of structures affected in schizophrenia. as indicated by correlated volumetric changes. (C) 2001 Elsevier Science B.V. All rights reserved.