Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia

A dysfunctional glutamatergic system has been implicated in the pathophysio logy of schizophrenia. The group III metabotropic glutamate receptor (mGluR ) types 7 acid 8 presynaptically inhibit glutamate release, thereby modulat ing glutamatergic transmission in the brain. We conducted association studi es to investigate the novel Tyr433Phe (mGluR7) variant and the 2846-C/T (mG luR8) polymorphism in schizophrenia. Both variants, present at high frequen cies, failed to demonstrate any significant association with schizophrenia (mGluR7 [Tyr433Phe] allele: P = 0.33: genotype: P = 0.63; mGluR8 [2846-C/T] allele: P = 0.72; genotype: P = 0.63). (C) 2001 Elsevier Science B.V. All rights reserved.