Self-assembled monolayer chemistry was used in combination with either mult
istream laminar flow or photolithography to pattern surface free energies i
nside microchannel networks. Aqueous Liquids introduced into these patterne
d channels are confined to the hydrophilic pathways, provided the pressure
is maintained below a critical value. The maximum pressure is determined by
the surface free energy of the liquid, the advancing contact angle of the
Liquid on the hydrophobic regions, and the channel depth. Surface-directed
liquid flow was used to create pressure-sensitive switches inside channel n
etworks. The ability to confine Liquid flow inside microchannels with only
two physical walls is expected to be useful in applications where a Large g
as-liquid interface is critical, as demonstrated here by a gas-liquid react
ion.