The clinical negotiation model proposed by Katon and Kleinman (1981) puts c
ulture at the very heart of the patient-doctor relationship. As opposed to
the asymmetric model that stresses an unequal power relationship between a
dominant physician and a powerless patient, this transactional model sugges
ts that we view the clinical encounter as the locus of a negotiation that t
akes place between two kinds of knowledge (lay and professional), and betwe
en two agendas: the doctor's and the patient's, According to such a model,
the doctor is taught to listen to the patient's own explanatory model of di
sease. Using an in-depth analysis of clinical encounters between perimenopa
usal women and female physicians, and of separate interviews with individua
l doctors and patients concerning their respective explanatory models, this
pilot study puts emphasis on both the limitations of a transactional model
and on the strategies deployed by doctors for enhancing the credibility of
hormonal replacement therapy.