Immunogenetic markers of hemoblastosis

Aim. To establish for hemoblastoses general and individual associations bet ween HLA genes and pre-disposition or resistance to malignant transformatio n of hemopoiesis. Material and methods. Antigens of class I and class II genes were determine d by microlymphocytotoxic test and DNA typing (PCR-SSP) in 30 patients with acute myeloblastic leukemia (AML), 47 patients with acute lymphoblastic le ukemia (ALL), 52 patients with chronic myeloblastic leukemia (CML), 58 pati ents with lymphogranulomatosis (LGM) and 224 donors. Results. HLA specificities were elucidated frequency of which was high in a ll the above nosological entities; Cw7 (RR 2.5 to 5.22), DRB1*11 (RR 2.3 to 4.88). Frequency of antigen B5 was high in three diseases (RR 2.14-2.6). A number of specificities have distribution deviations typical for only one or two diseases (A19-AML and CML, B27 - ALL, DRB1*08 - AML). The HLA-gene w as detected the frequency of which was low in three diseases - DRB1*07 (RR 0.39 to 0.11). Individual preventive HLA genes for AML, ALL, LGM were A2, B 8; A1, B8, B40; DRB1*01, respectively. Conclusion. Cw7, DRB1*11, B5 are HLA-specificities marking hemopoiesis pred isposition to malignant transformation in general. Development into a certa in nosological entity depends on combination of general HLA-genes with mark ers of individual hemoblastosis. DRB1*07 is a general preventive gene. Prev entive HLA genes can be also individual for the above hematological disease s.