Synthesis of furano[2,3-c]-pyran-3-one and thieno[2,3-c]-pyran-3-one derivatives through the coupling of 3-alkynyl-2-heteroaromatic carboxaldehydes with Fischer carbene complexes
Ys. Zhang et Jw. Herndon, Synthesis of furano[2,3-c]-pyran-3-one and thieno[2,3-c]-pyran-3-one derivatives through the coupling of 3-alkynyl-2-heteroaromatic carboxaldehydes with Fischer carbene complexes, TETRAHEDR L, 42(5), 2001, pp. 777-779
The coupling of Fischer carbene complexes with 3-alkynyl-2-heteruaromatic c
arboxaldehyde derivatives has been examined. The reaction affords pyrones f
used to furans or thiophenes in a single step. The compounds are stable eno
ugh for isolation. If the carbene complex features a remote alkene substitu
ent, a subsequent Diels-Alder reaction can occur. (C) 2001 Elsevier Science
Ltd. All rights reserved.