This study aimed to evaluate the ability of speed of sound (SOS) measured a
t the phalanges to estimate simulated wrist fracture load and stress. SOS w
as measured along the proximal phalanges of the second, third and fourth fi
ngers using an ultrasound (US) system operating in axial transmission mode.
The bone mineral density (BMD) of the radius and the phalanges was also me
asured with quantitative computed tomography (QCT) and dual x-ray absorptio
metry (DXA), and the combined cortical thickness (CCT) of the phalanges was
measured from hand radiographs. After the measurements were completed, the
radius was excised from the cadaver, embedded in polymethylmethacrylate an
d tested to failure on a servohydraulic testing machine. The configuration
of the radius was chosen to simulate a fall onto the hand. Linear regressio
n analysis showed a highly significant correlation between SOS (r = 0.76-0.
94, p < 0.001), CCT (r = 0.86-0.90, p < 0.001) and BMD (r = 0.92-0.96, p <
0.0001) in the three proximal phalanges measured. SOS, BMD and CCT were sig
nificant predictors of fracture load (r = 0.60-0.69, p < 0.03) and stress (
r = 0.65-0.77, p < 0.02). Cortical area and bone mineral content (BR IC) of
the radius were consistently higher predictors of fracture load (r = 0.76-
0.82, p < 0.01 for area and r = 0.78-0.88, p < 0.01 for BMC) than BMD. The
correlation of BMC and area was poorer with fracture stress. In a step-wise
regression analysis using both phalangeal BMD and SOS, only SOS remained a
significant predictor of fracture stress. In forward stepwise regression a
nalysis, both cortical area and SOS were entered into the regression model
to estimate fracture load. Only SOS remained significant in the model for e
stimating fracture stress. Phalangeal BMD was only entered in the combined
model with the cortical area at the 4% site (r = 0.84, p = 0.002). Phalange
al SOS is a useful parameter in the assessment of bone status of the radius
. (C) 2001 World Federation for Ultrasound in Medicine & Biology.