SYNTHESIS OF NOVEL C-2-SYMMETRICAL DIAMINO THIOETHERS DERIVED FROM AMINO-ACIDS

Chiral beta-amino alcohols 2, available from natural alpha-amino acids by reduction, have been converted in a sequence of N-protection, O-ac tivation, thioether formation, and deprotection to novel C-2-symmetric al beta,beta'-diamino thioethers 1, which shall serve as chiral triden tate ligands in late transition metal complexes. Optical purity of com pounds 1 was established by amide formation with (+)-O-acetylmandelic acid.