IMPROVED SYNTHESIS OF ANHYDROHEXITOL BUILDING-BLOCKS FOR OLIGONUCLEOTIDE SYNTHESIS

Authors
DEBOUVERE B KERREMANS L ROZENSKI J JANSSEN G VANAERSCHOT A CLAES P BUSSON R HERDEWIJN P
Citation
B. Debouvere et al., IMPROVED SYNTHESIS OF ANHYDROHEXITOL BUILDING-BLOCKS FOR OLIGONUCLEOTIDE SYNTHESIS, Liebigs Annalen, (7), 1997, pp. 1453-1461
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
7
Year of publication
1997
Pages
1453 - 1461
Database
ISI
SICI code
0947-3440(1997):7<1453:ISOABF>2.0.ZU;2-8
Abstract
The synthesis of the four building blocks used for the preparation of hexitol nucleic acids were optimized. The nucleoside analogues with a purine base moiety are best prepared by a nucleophilic substitution re action, whereas the pyrimidine nucleosides can best be obtained using Mitsunobu-type conditions.