CHEMISTRY OF THE GINKGOLIDES .8. SYNTHESIS AND CRYSTAL-STRUCTURE OF ADIMERIC 14,15,16-TRINORGINKGOLIDE DERIVATIVE

Authors
WEINGES K SCHICK H IRNGARTINGER H OESER T
Citation
K. Weinges et al., CHEMISTRY OF THE GINKGOLIDES .8. SYNTHESIS AND CRYSTAL-STRUCTURE OF ADIMERIC 14,15,16-TRINORGINKGOLIDE DERIVATIVE, Liebigs Annalen, (7), 1997, pp. 1607-1609
Citations number
8
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
7
Year of publication
1997
Pages
1607 - 1609
Database
ISI
SICI code
0947-3440(1997):7<1607:COTG.S>2.0.ZU;2-M
Abstract
Treatment of the enol acetate thoxy-2,3-didehydro-14,15,16-trinorginkg olide([2]) (2) with potassium osmate/N-methylmorpholine N-oxide in ace tone/acetic acid solution did not yield the expected 2-hydroxy-3-oxo d erivative 3, but the dimeric ginkgolide thoxy-14,15,16-trinorginkgolid o)[2,3-c;2',3'-e-]-1 '',4 ''-dioxan-3,3'-diol (4a). By acid hydrolysis , 4a was converted to the MOM-deprotected dimeric product 4b. The stru cture of 4a was elucidated by crystal structure analysis.