Influence of gender on early and one-year clinical outcomes after saphenous vein graft stenting

Compared with men, women may have a worse prognosis after native coronary r evascularization. However, the influence of gender on clinical outcomes aft er saphenous vein graft (SVG) stenting is unknown. The purpose of this stud y was to compare early and 1-year clinical outcomes between men and women a fter stent implantation in SVG. A total of 1,199 consecutive patients with 1,858 SVG lesions were studied. Procedural success, in-hospital events, and late clinical outcomes were compared between men (n = 951) and women (n = 248). Overall procedural success was similar between men and women (97% vs 96%, p = NS). However, in-hospital (3.2% vs 1.6%, p = 0.07) and 30-day cumu lative (4.4% vs 1.9%, p = 0.02) mortality rates were higher in women than i n men. In addition, women had a higher incidence of vascular complications (12% vs 7.3%, p 0.006) and postprocedural acute renal failure (8.1% vs 4%, p = 0.02). At 1-year follow-up, mortality was 13% in women and 11% in men ( p = NS) and target lesion revascularization was 18% versus 23%, respectivel y (p = NS). By multivariate regression analysis, independent correlates of in-hospital mortality were female gender (odds ratio [OR] 3.6, confidence i nterval [Ct] 1.0 to 12.5, p = 0.05) and left ventricular ejection fraction (OR 0.9, Cl 0.9 to 1.0, p = 0.01). Female gender was found to predict 30-da y mortality (OR 2.5, CI 1.1 to 5.5, p 0.02). The sole predictor of 1-year m ortality was diabetes mellitus (OR 1.6, Cl 1.1 to 2.3, p = 0.01). This stud y shows that women compared with men treated with stent implantation in SVG lesions have (1) a trend toward higher in-hospital mortality, (2) higher r isk of 30-day mortality, (3) increased incidence of vascular complications and postprocedure acute renal failure, and (4) similar 1-year clinical outc ome. (C) 2001 by Excerpta Medica, Inc.