Acute generalized exanthematous pustulosis disclosing acute parvovirus B19infection

Background, We report a case of typical exanthematous pustulosis rash that was particularly severe both clinically and biologically. Laboratory tests led to the diagnosis of acute parvovirus B19 infection. Case report, A 23-year-old man with no past medical history developed fever with an erythematous pustulosis rash predominantly involving the folds. Bl ood cell count revealed hyperleukocytosis. There was no previous drug intak e. This skin reaction was associated with severe systemic manifestations in cluding hypovolemic shock, and hematologic and metabolic disturbances. Viro logy tests revealed acute parvovirus B19 infection. The hospital physician caring for this patient also presented evidence of acute parvovirus B19 inf ection. Discussion. The clinical features and the course of this skin eruption were typical of generalized exanthematous pustulosis. We discuss the rare viral causes of acute generalized exanthematous pustulosis and compare our case with a previously reported case of acute generalized exanthematous pustulos is with mononucleosic syndrome in a patient with no prior drug intake. The clinical and biological manifestations of this case were similar to drug hy persensitivity syndrome.