Sustained response of sarcomatoid renal-cell carcinoma to MAID chemotherapy: Case report and review of the literature

The sarcomatoid variant of renal-cell carcinoma (SRCC), a clinically aggres sive subtype of renal parenchymal tumors, is typically resistant to systemi c treatments and carries a poor prognosis. The authors report a case of a 5 7-year-old male with advanced SRCC who had a durable complete response afte r MAID (mesna, adriamycin, ifosfamide and dacarbazine) chemotherapy, and re mains free of disease four years after completing treatment. To the authors ' knowledge, this is the first report of a remission from MAID chemotherapy in SRCC. A review of published literature revealed occasional responses af ter systemic chemotherapy. Notably, all responses were seen with doxorubici n containing regimens, suggesting that doxorubicin is a critical component in chemotherapy regimens for SRCC.