Child and adolescent depression is one of the greatest health concerns in o
ur society today. This article critically reviews the literature on the psy
chopharmacologic treatment of adolescent depression. Although double-blind
studies have failed to show the efficacy of tricyclic antidepressants, more
recent evidence has emerged for the use of selective serotonin reuptake in
hibitors in this population. However, placebo-controlled, double-blind stud
ies are limited, and many of the other newer antidepressants have yet to be
investigated in treating adolescent depression. Nonetheless, antidepressan
ts are widely prescribed to these populations, and psychiatric nurses are a
ctively involved in assessing and monitoring the need for these medications
in adolescents. Copyright (C) 2001 by W.B. Saunders Company.