PREPARATION AND IN-VITRO ANTIPROTOZOAN ACTIVITY OF NEW NAPHTHOIMIDAZOLEDIONES

Authors
VANELLE P DONINI S MALDONADO J CROZET MP DELMAS F GASQUET M TIMONDAVID P
Citation
P. Vanelle et al., PREPARATION AND IN-VITRO ANTIPROTOZOAN ACTIVITY OF NEW NAPHTHOIMIDAZOLEDIONES, European journal of medicinal chemistry, 32(6), 1997, pp. 523-528
Citations number
25
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
32
Issue
6
Year of publication
1997
Pages
523 - 528
Database
ISI
SICI code
0223-5234(1997)32:6<523:PAIAAO>2.0.ZU;2-3
Abstract
The original compound bearing the coplanar quinone and imidazole syste ms, hydro-1-methyl-1H-naphtho[2,3-d]imidazol-4,9-dione reacted with va rious nitronate anions to afford, in moderate to good yields, new naph thoimidazolediones bearing a trisubstituted ethylenic double bond at t he 2-position. These compounds were evaluated as potential antiprotozo an agents. Some derivatives were found to have a significant activity, but the naphthoquinone was found to be a less efficient pharmacophore than the nitro group.