Gm. Vandam et al., PRIMARY BILIARY-CIRRHOSIS - DUTCH APPLICATION OF THE MAYO MODEL BEFORE AND AFTER ORTHOTOPIC LIVER-TRANSPLANTATION, Hepato-gastroenterology, 44(15), 1997, pp. 732-743
Background/Aims: A retrospective study of primary biliary cirrhosis (P
BC) was performed to study the Original Mayo Model for predicting surv
ival by a Dutch data-set of patients, presentation of disease progress
ion; assessment of liver transplantation, prediction of post-transplan
tation survival; and the addition of two laboratory variables to the O
riginal Mayo Model. Materials and Methods: Survival of 83 patients, 37
of whom underwent transplantation, were studied. Mean follow-up was 6
.0+/-0.45 SEM years. Risk score at diagnosis, platelet count, and seru
m sodium were analyzed in a Cox model. Results: The Original Mayo Mode
l estimated survival for low-, medium-, and high-risk groups accuratel
y and it also presented disease progression. Baseline Mayo risk score
in a Cox model had a regression coefficient of 1.01, indicating an exc
ellent predictor p < 0.0001. Platelet count was a predictor of surviva
l (p < 0.002), whereas serum sodium did not (p = 0.67). A new model co
mbined of the Original Mayo risk score and platelet count predicted su
rvival in high-risk patients somewhat better compared to the Original
Mayo Model. With both models, liver transplantation had a significant
beneficial effect on, survival (p < 0.001). The scores revealed no sig
nificant influence (p = 0.47) for overall post-transplantation surviva
l. Conclusions: The Original Mayo Model remains the model of choice fo
r patients with PBC for prognostication from 3-8 years, is a useful to
ol in the assessment of liver transplantation but not an indicator of
post-transplantation survival. Platelet count showed to have additiona
l prognostic value. A new model combined of platelet count and the Ori
ginal Mayo risk score did predict survival in high-risk groups slightl
y better compared to the Original Mayo Model.