A richer conceptualization of "exposure" for epidemiological studies of the "EMF mixture"

Controversial laboratory results and the now discredited "wire code paradox " suggest that epidemiologists might miss something if they measured only 6 0 Hz fields and summarize time series of exposure with only a time integral . This has led to the question of how else the exposure issue could be addr essed. This paper proposes a potential answer to this question by borrowing concepts from pharmacology. The paper briefly explores how the limitations of current analysis can lead to poor public policy decisions. The paper th en uses a pharmacological analogy to highlight such concepts as "mixture," "ingredient," "dose duration." "dosing schedule." and "windows of biologica l vulnerability" to guide an epidemiologist in choosing what to measure. Th e authors point out that any candidate "ingredient" or exposure metric must be associated with wire code or spot measurements if it is to explain prev ious epidemiological associations. This helps eliminate many "ingredients" and exposure metrics from consideration. The authors then describe how they applied these concepts in the design of a prospective study of miscarriage and EMF exposure. Bioelectromagnetics Supplement 5:S48-S57, 2001. (C) 2001 Wiley-Liss. Inc.