Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

The regulation of nutrient transport by both cytokines and oncogenes has be en linked to haemopoietic cell survival. In this study, we found that activ ation of Bcr-Abl protein tyrosine kinase was associated with the stimulatio n of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr-Abl upr egulation of glucose transport was mediated by phosphatidylinositol-3-kinas e. The observation that Bcr-Abl can regulate glucose transport in a CML cel l model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase o f CML.