Therapeutic aspects of cannabis and cannabinoids

Background Review commissioned in 1996 by the Department of Health Aims Assess therapeutic profile of cannabis and cannabinoids. Method Medline search, references supplied by DOH and others, and personal communications. Results and Conclusions Cannabis and some cannabinoids are effective antiem etics and analgesics and reduce intraocular pressure. There is evidence of symptom relief and improved well - being in selected neurological condition s, AIDS and certain cancers. Cannabinoids may reduce anxiety and improve sl eep. Anticonvulsant activity requires clarification. Other properties ident ified by basic research await evaluation. Standard treatments For many rele vant disorders are unsatisfactory Cannabis is safe in overdose but often pr oduces unwanted effects, typically sedation, intoxication, clumsiness, dizz iness, dry mouth, lowered blood pressure or increased heart rate. The disco very of specific receptors and natural ligands may lead to drug development s. Research is needed to optimise dose and route of administration, quantif y therapeutic and adverse effects, and examine interactions.