Alterations in glucose metabolism in non-endocrine disease: potential implication for wasting

Citation
Hp. Sauerwein et Ja. Romijn, Alterations in glucose metabolism in non-endocrine disease: potential implication for wasting, CLIN NUTR, 20(1), 2001, pp. 2-8
Citations number
54
Categorie Soggetti
Endocrynology, Metabolism & Nutrition
Journal title
CLINICAL NUTRITION
ISSN journal
02615614 → ACNP
Volume
20
Issue
1
Year of publication
2001
Pages
2 - 8
Database
ISI
SICI code
0261-5614(200102)20:1<2:AIGMIN>2.0.ZU;2-S
Abstract
Diseases like sepsis, AIDS and cancer can induce an increase in endogenous glucose production. Sepsis and cancer induce insulin resistance whereas inc reased insulin sensitivity is found in AIDS. Non-oxidative glucose disposal is increased in sepsis and cancer but normal in AIDS. These differences in glucose metabolism between these three diseases characterized by wasting p reclude energy-requiring changes in glucose metabolism as the common denomi nator for wasting in ail three diseases. Moreover, the energy requirements of the changes in glucose metabolism induced by cancer and sepsis are rathe r small. Consequently, alterations in glucose metabolism are pathophysiolog ical epiphenomena rather than a cause of wasting in disorders like sepsis, cancer and AIDS. (C) 2000 Harcourt Publishers Ltd.