The use of phenol to achieve chemexfoliation of facial tissue, following ei
ther the standard Baker-Gordon formula or modifications of that formula, ca
n produce a range of results depending on a variety of factors. This articl
e--based on 16 new cases of modified phenol peels, three human biopsy studi
es, and one triple-blind study--examines the relative roles of phenol conce
ntration, croton oil concentration, and application technique in the produc
tion of the chemical peel result. Results of this data suggest that the app
lication technique is more important than the concentration of phenol or cr
oton oil and underscore the importance of standardizing the application pro
cess.