Stress-induced hyperglycemia is common in the ICU. Major contributing facto
rs include excessive counterregulatory hormones, cytokine release and admin
istration of excessive dextrose support. Evidence that aggressive managemen
t of hyperglycemia in the ICU is beneficial is sparse, and many studies are
retrospective. Correction of hyperglycemia clearly improves mortality in p
atients with myocardial infarction (MI), and may reduce subsequent infectio
us complications in surgical patients.