Parvovirus B19 infection in an HIV-infected patient with febrile pancytopenia and acute hepatitis

The case of a 34-year-old male patient with HIV infection referred for seve re febrile pancytopenia is reported. Clinical and laboratory evaluations re vealed acute hepatitis B infection and concomitant parvovirus B19 infection . The patient died just before treatment with immune globulin was to be adm inistered. Parvovirus B19 has been found to cause a wide variety of hematol ogic disorders such as neutropenia, thrombocytopenia, pancytopenia, and hem ophagocytic syndrome. The role of parvovirus B19 in the pathogenesis of bon e marrow or liver involvement is briefly discussed.