Does the A3333G mutation in the CACNL1A3 gene, detected in malignant hyperthermia, also occur in central core disease?

Malignant hyperthermia (MH) and central core disease (CCD) are two conditio ns associated with susceptibility to volatile anesthetics and depolarizing muscle relaxants. The gene RYR1, encoding the Ca2+ release channel of skele tal muscle sarcoplasmic reticulum, is responsible for about 50% of the case s of MH and some cases of CCD. However, genetic heterogeneity occurs in MH and a mutation in a second gene (CACLN1A3), encoding the alpha1-subunit of the dihydropyridine (DHP) channel, has recently been found in a large MH Fr ench family. The presence of this mutation in patients with CCD has not yet been reported, In this study, we analyzed the A3333G mutation in 5 unrelat ed patients affected by CCD and 31 MH-susceptible relatives (from 19 MH fam ilies) and did not find this mutation in any of them, Nevertheless, the rep ort of data on newly described mutations in different populations is import ant to estimate the contributions of each gene mutation to the phenotype of MH and CCD.