K. Morimoto et al., INCREASED LEVELS OF MESSENGER-RNA FOR BETA-SUBUNIT BUT NOT ALPHA-SUBUNIT OF CALMODULIN KINASE-II FOLLOWING KINDLED SEIZURES, Brain research bulletin, 43(4), 1997, pp. 375-380
We studied levels of mRNA for the alpha- and beta-subunits of calmodul
in (CaM) kinase II using the amygdaloid kindling model of epilepsy. Th
ere were significant increases in mRNA for the beta-subunit of CaM kin
ase II in the hippocampus 4-24 h after stage 5-kindled seizures. Moreo
ver, this mRNA was significantly increased by 20.0-26.5% in the bilate
ral dentate gyrus 8 to 24 h after kindled seizures, The beta-subunit m
RNA was also significantly increased by 13.5-19.0% in the CA3 on the s
ide ipsilateral to the stimulation, 4 to 8 h after kindled seizures. m
RNA for the alpha-subunit of CaM kinase II was not significantly chang
ed in the regions examined for up to 24 h after the kindled seizures.
These results suggest that CaM kinase II mediates the molecular proces
ses that follow kindled seizures, It is possible that increases in CaM
kinase It-dependent protein phosphorylation are associated with the p
lastic changes in kindling. (C) 1997 Elsevier Science Inc.