B. Walder et al., Evaluation of two processed EEG analyzers for assessment of sedation aftercoronary artery bypass grafting, INTEN CAR M, 27(1), 2001, pp. 107-114
Objectives: Processed EEG monitoring has been suggested for sedation depth
evaluation in intensive care unit (ICU) patients. The present study investi
gated the efficacy of two processed EEG monitors using SEF90% or SEF95% and
BIS to differentiate between conscious (Ramsay score 4) and unconscious se
dation (Ramsay score 6).
Design and setting: Prospective, randomized trial in a surgical ICU of a un
iversity teaching hospital.
Patients: Patients recovering from elective coronary bypass grafting.
Intervention: One of two EEG analyzers was installed (A: Aspect A-1000 meas
uring SEF95% and BIS; D: Drager pEEG measuring SEF90%). At ICU admission un
conscious sedation (Ramsay score 6), and at three 30-min intervals consciou
s sedation (Ramsay score 4) were investigated.
Measurements and results: Fourteen patients were monitored by A and 14 by D
. The interindividual variability (coefficient of variation 32-69%) was lar
ge for all three processed EEG methods. SEF90% of analyzer D and BIS of ana
lyzer A showed a statistically significant difference between unconscious a
nd conscious sedation (11 +/- 3 and 17 +/- 6 Hz, p = 0.005; 74 +/- 10 and 8
3 +/- 10,p = 0.02). Positive and negative predictive values for SEF90% of a
nalyzer D (0.57, 95% CI 0.34-0.77; and 0.92, 95% CI 0.64-0.99) and BIS of a
nalyzer A (0.55, 95% CI 0.32-0.76; and 0.87, 95% CI 0.60-0.98) were too low
for discrimination between conscious and unconscious sedation.
Conclusions: The use of processed EEG monitoring cannot be recommended for
assessing sedation depth after cardiac surgery.