Solubilization of rapamycin

Authors
Simamora, P Alvarez, JM Yalkowsky, SH
Citation
P. Simamora et al., Solubilization of rapamycin, INT J PHARM, 213(1-2), 2001, pp. 25-29
Citations number
19
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173 → ACNP
Volume
213
Issue
1-2
Year of publication
2001
Pages
25 - 29
Database
ISI
SICI code
0378-5173(20010201)213:1-2<25:SOR>2.0.ZU;2-7
Abstract
The solubilization of rapamycin, a poorly water soluble investigational imm unosuppressive drug, by facilitated hydrotropy is presented. Partially wate r-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic a cid) can be solubilized by water-miscible cosolvents, such as ethanol and p ropylene glycol. Once solubilized, the partially miscible aromatic solute b ecomes a solubilizing agent. This technique yielded a dramatic(> 1000-fold) increase in the aqueous solubility of rapamycin. (C) 2001 Elsevier Science B.V. All rights reserved.