INTRAHEPATIC CHOLESTASIS DUE TO SYSTEMIC MASTOCYTOSIS - A CASE-REPORTAND REVIEW OF LITERATURE

A 35-yr-old female presented with symptoms of obstructive jaundice, Li ver biopsy, bone marrow aspiration, and biopsy revealed systemic masto cytosis and acute myeloid leukemia, The Liver biopsy specimen showed i nfiltration of mast cells within portal tracts with periductal and por tal edema, irregularity of interlobular duct epithelium, and centrizon al cholestasis. Endoscopic retrograde cholangiography was normal, Foll owing chemotherapy treatment with idarubicin and cytarabine for seven days for AML, the bilirubin levels continued to increase for two weeks and then decreased, reaching normal levels in two months, Infiltratio n of mast cells in the liver leads to hepatomegaly, liver function abn ormality and rarely portal hypertension, Intrahepatic cholestasis due to systemic mastocytosis has never been reported, We report a rare cas e of systemic mastocytosis causing intrahepatic cholestasis that resol ved with remission of AML following chemotherapy.